Prof. Roeland Van Wijk 1. The Dutch Research Group at the IIB 1.1. Participants Roeland Van Wijk Jan Souren Elida Boon Eduard Van Wijk Rafael Gaya Moreno 1.2. Locations The Dutch Research Group, participating in the IIB is working at the IIB-Neuss location and two other places. The main location is the IIB Institute in Neuss (Roeland Van Wijk, Rafael Gaya Moreno, and Eduard Van Wijk). The second location is at the Department of Molecular Cell Biology, Utrecht University, The Netherlands (Roeland Van Wijk and Elida Boon), the third at MeLuNa, Hilversum, The Netherlands (Roeland Van Wijk, Jan Souren, and Eduard Van Wijk) 1.3. Activities At the IIB-Neuss the faculities for biophoton measurements are used for basic experimental research in two araes : Mechanism of biophoton emission of animal and plant cells, in particular the relationship between delayed luminescence and coherence of biological domains. Imaging biophoton emission from organisms, including humans, using the available whole-body counting-biophoton equipment. At the Department of Molecular Cell Biology, Utrecht Univesity, the facilities for high-quality (video) microscopy are used for : Imaging of intracellular dynamics of cell organelles. Developments of methods for quantification of coherent biological domains. At MeLuNa, Hilversum one biophoton equipment is available for two areas of research : Delayed luminescence of natural products in relation to biological quality. Influence of consciousness on biophoton fields of organisms
2. Brief Curricula of Principal Investigators
2.1 Roeland Van Wijk Born in 1942 in The Netherlands, Degree in Biology (1965, Utrecht University), specialisms Biophysical Chemistry and Molecular Biology. Received Ph.D. in 1968 with his thesis on ‘Alpha-Glucosidase Synthesis, Respiratory Enzymes and Catabolite Repression in Yeast’. Senior scientist and Assistant Professor at the Utrecht University, Department of Molecular Cell Biology. Visiting scientist at several research institutes (1971/72 : Jewish Hospital and Research Center, Denver ; 1976 : University of Colorado, Denver ; 1982 : Friedrich Miescher Institute, Basel ; since 1982 : scientific collaboration on biophoton research with Fritz-Albert Popp). Head of the Research Unit for Complimentary Medicin (Utrecht University) in 1985-1995. Research projects : Metabolic regulation in anti-directional metabolic pathways Metabolic programs, differentiation and cancer Relationship between stress adaptation, differentiation, and growth regulation Biophoton measurements of mammalian (tumor) cells Molecular basis of stress and the concept of self-healing Role of extracellular collagen matrix in regulation of cell growth and differentiation Cellular stress and free radical production Heart cell-collagen matrix as model for biological coherent metabolic programs. Coherency of metabolic programs and biophoton characteristics Development of biophoton measurements to monitor quality of biological materials Development of the concept of Basic-Bio-Regulatory System Human skin characteristics in disease and electrodermal measurement devices The concept of self-healing at organismal level Self-healing and the principles in homeopathy Healing intention in social life and medical practice Coherent domains in social organizations and biophoton emission Further details : see Development of Domain Energy Program. Faculty staff member of the California Institute for Human Studies, Vice President of the International Institute of Biophysics in Neuss, Member of the Advisory Board of Journal for Alternative Therapies, Editor-in chief of the Dutch Journal for Integral Medicine
2.2. Elida K. Boon-Niermeijer Born in 1939 in The Netherlands, Degree in Biology (1965, Utrecht University), specialism Zoology. Senior scientist at the Utrecht University , Department of Zoology, section Gene Expression and Early Development. Received her Ph.D. in 1987 with a thesis on ‘Influence of stress on early development of Limnaea stagnalis’ Research projects : Response on stress of a developing organism Delayed luminescence of seeds in relation to germination capacity Delayed luminescence of leaves during plant life cycle Protection by adaptogens against stress Growth, differentiation, intracellular streaming and domain formation of Acetabularia cells Training to Cranio-Sacral Therapist at the Upledger Institute Europe. Interested in the phenomenon of tissue memory, i.e. mechanism of injury storage in tissues, its transfer to consciousness, and the application of release mechanisms in medical practice.
2.3. Jan Souren Born in 1958 in The Netherlands, Degree in Biology (1985, Utrecht University), specialisms Molecular Cell Biology and Biochemistry. Received his Ph.D. in 1993 with a thesis on ‘Mammalian Cells in a Collagen Type-1 Microenvironment. 1993-1999 Post doc researcher at the Department of Molecular Cell Biology, section Gene Expression and Stress Research. Projects : Role of extracellular matrix in regulation of cell growth and differentiation Cellular stress and free radical production Application of luminescence techniques in proteotoxicity research Development of heart cell-collagen matrix as model for heart research. Development of biophoton measurements to monitor quality of biological materials Since 2000, Head of the Imaging Laboratory of the Fred Foundation (Hilversum, The Netherlands). Interested in the imaging of subtle energy patterns, and in electrodermal measurement devices.
2.4. Eduard Van Wijk Born in 1967 in The Netherlands, Degree in Psychology (1994, University of Nijmegen), specialism Experimental and Neuropsychology. Research Assistant at the Nijmegen Institute of Cognition and Information at the Department of Cognitive Neuroscience, Nijmegen. Received his Ph.D. in 1998 with a thesis on ‘Context, Learning, and Remembering’. Since 2000, Researcher at MeLuNa, project ‘Intention, Complementarity, Coherence and Healing’ Projects : Psychopharmacology and cognition Diabetes, depression and electrodermal activity Occasion setting by contextual and discrete stimuli Consciousness and biophoton emission
2.5. Name : Rafael Gaya Moreno

3. The program on Energy Domains and Biophotons

3.1 History of Program Development

3.2. Present topics of research

4. Publications

4.1. Major List of Publications (in chronological order).

1.
H.P.J. Bloemers, R. Van Wijk, W.H. Hupje, C.J.M.Engel and V.V. Koningsberger.
The apparent synthesis of a-glucosidase in a subcellular system derived from protoplasts of Saccharomyces carlsbergensis.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen B 70, 68-76 (1967)

2.
R. Van Wijk
a-Glucosidase synthesis, respiratory enzymes and catabolite repression in yeast.
I. The effects of glucose and maltose on inducible a-glucosidase synthesis in protoplasts of Saccharomyces carlsbergensis.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen C 71, 60-71 (1968)

3.
R. Van Wijk
a-Glucosidase synthesis, respiratory enzymes and catabolite repression in yeast.
II. The effects of glucose on inducible and on constitutive a-glucosidase synthesis in whole yeast cells.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen C 71, 72-79 (1968)

4.
R. Van Wijk
a-Glucosidase synthesis, respiratory enzymes and catabolite repression in yeast
III. The correlation between the synthesis of a-glucosidase and that of some respiratory enzymes.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen C 71, 137-151 (1968)

5.
R. Van Wijk
a-Glucosidase synthesis, respiratory enzymes and catabolite repression in yeast. Part IV A. Studies on the level of protein synthesis at which repression and induction of a-glucosidase synthesis occur.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen C 71, 293-301 (1968)

6.
R. Van Wijk
a-Glucosidase synthesis, respiratory enzymes and catabolite repression in yeast. Part IV B. Studies on the level of protein synthesis at which repression and induction of a-glucosidase synthesis occur.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen C 71, 302-313 (1968)

7.
R. Van Wijk
Catabolite repression and lagtime during a-glucosedase synthesis in protoplasts of Saccharomyces carlsbergensis.
Anthonie van Leeuwenhoek 35, 11 (1969)

8.
R. Van Wijk, J. Ouwehand, T. van de Bos and V.V. Koningsberger.
Induction and catabolite repression of a-glucosidase synthesis in protoplasts of Saccharomyces carlsbergensis.
Biochimica Biophysica Acta 186, 178-191 (1969)

9.
R. Van Wijk, K.W. van de Poll and G.A.G. Speziali.
Catabolite repression of a-glucosidase synthesis in yeast during nitrogen limitation. Proceedings Koninklijke Nederlandse Akademie van Wetenschappen B 73, 357-371 (1970)

10.
K.W. van de Poll and R. Van Wijk
Repression and derepression of allantoinase synthesis in protoplasts of Saccharomyces carlsbergensis. Part IV. Effect of the carbon and the nitrogen source on allantoinase and a-glucosidase synthesis in cells.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen B 73, 372-380 (1970)

11
G.A.G. Speziali and R. Van Wijk
Cyclic 3',5'AMP phosphodiesterase of Saccharomyces carlsbergensis.. Inhibition by adenosine 5’-triphosphate, inorganic pyrophosphate and inorganic polyphosphate.
Biochimica Biophysica Acta 235, 466-472 (1971)

12.
R. Van Wijk and T.M. Konijn
Cyclic 3',5'AMP in Saccharomyces carlsbergensis under various conditions of catabolite repression.
FEBS Letters 13, 184-186 (1971)

13.
J.H. Slavenburg, R. Van Wijk and G. Zoutewelle
Glutathione-like peptides in S.carlbergensis. II. Effects of GSH and some of its derivatives on the induced synthesis of a-glucosidase of Saccharomyces carlsbergensis.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen C 75, 55-66 (1972)

14.
J. Van Rijn and R. Van Wijk
Differential sentivities of the two malate dehydrogenases and the maltose permease to the effect of glucose in Saccharomyces carlsbergensis.
Journal of Bacteriology 110, 477-484 (1972)

15.
J. Ouwehand and R. Van Wijk
Regulation of maltase and a-methylglucosidase synthesis in genetically defined strains of Saccharomyces carlsbergensis.
Molecular and general Genetics 117, 30-38 (1972)

16.
R. Van Wijk, K. Clay and W.D. Wicks
Effects of derivatives of cyclic 3',5'AMP on the growth, morphology and gene expression of cultured hepatoma cells.
Federation Proceedings 31, 439A (1972)

17.
R. Van Wijk, W.D. Wicks and K. Clay
Effects of derivatives of cyclic 3',5'AMP monophossphate on the growth,morphology and gene expression of hepatoma cells in culture.
Cancer Research 32, 1905-1911 (1972)

18.
R. Van Wijk, W.D. Wicks, M.M. Bevers and J. Van Rijn
Rapid arrest of DNA synthesis by N6,02'-dibutyryl cyclic adenosine 3',5' monophosphate in cultured hepatoma cells.
Cancer Research 33, 1331-1338 (1973)

19.
W.D. Wicks, R. Van Wijk, K. Clay, C. Bearg, M.M. Bevers and
J. Van Rijn
Regulation of growth rate, DNA synthesis and specifif protein synthesis by derivatives of cyclic AMP in cultured hepatoma cells.
In "The Role of Cyclic Nucleotides in Carcinogenesis". Eds. J.Schultz and H.G.Grattzner . Academic Press. New York (1973) pp.103-124.

20.
W.D. Wicks, R. Van Wijk and J.B.McKibbin
Stimulation of enzyme synthesis and inhibition of DNA synthesis and growth rate by cyclic AMP derivatives in cultured hepatoma cells.
Advances in Enzyme Regulation 11, 117-135 (1973).

21.
J.H. Slavenburg and R. Van Wijk
Catabolite repression of a-glucosidase synthesis under conditions of starvation in Saccharomyces carlsbergensis.
Proceedings Koninklijke Nederlandse Akademie van Wetenschappen C 76, 382-391 (1973)

22.
R. Van Wijk, J.H. Slavenburg and K.W. van de Poll
Levels of glycolytic intermediates, adenosine phosphates and polyphosphate in Saccaromyces carlsbergensis under various degrees of catabolite repression. Proceedings Koninklijke Nederlandse Akademie van Wetenschappen C 76, 512-527 (1973)

23.
H. Van Rijn, M.M. Bevers, R. Van Wijk and W.D. Wicks
Regulation of phosphoenolpyruvate carboxykinase and tyrosine transaminase in hepatoma cell cultures. III. Comparative studies in H35, HTC, MH1C1 and RLC cells.
Journal of Cell Biology 60, 181-191 (1974)

24.
M.M. Bevers, R.A.E. Smits, J. Van Rijn and R. Van Wijk
Heat treatment of rat liver adenosine 3',5'-monophosphate phosphodiesterase. Kinetic characterization of the low affinity enzyme.
Biochimica Biophysica Acta 341, 120-128 (1974)

25.
M.M. Bevers, J. Van Rijn and R. Van Wijk
A comparative study on the metabolism of N6,02'-dibutyryl adenosine 3',5'-monophosphate in various rat hepatoma cell lines in culture.
FEBS Letters 72, 275-278 (1976)

26.
R. Van Wijk, J.W. Koontz and W.D.Wicks
Studies on the localization of the serum control point in the cell cycle of Reuber H35 hepatoma cells.
In Vitro 13, 162 (1976)

27.
R. Van Wijk, K.W. van de Poll, J.W.C. Amesz and W.L.M. Geilenkirchen
Studies on the variation in generation times of rat hepatoma cells in culture.
Experimental Cell Research 109, 371-379 (1977)

28
W.L.M. Geilenkirchen, J. Jansen, R. Coosen and R. Van Wijk
Changes in the content of cyclic AMP and cyclic GMP in eggs of Mactra solidissima during the second cleavage cycle.
Cell Biology International Reports 1, 419-426 (1977)

29.
H. Volman and R. Van Wijk
A morphometric and biochemical study of the mitochondria in several hepatoma cell lines and in isolated hepatocytes (FEBS Abstract, 1978);

29A
H. Volman
A morphologic and morphometric study of the mitochondria in several hepatoma cell lines and in isolated hepatocytes.
Virchows Archives. B. Cell Pathology. 26, 249-259 (1978)

30.
D.H.J. Schamhart, K.W. van de Poll and R. Van Wijk
Comparative studies of glucose metabolism in HTC, RCL, MHC and Reuber H35 hepatoma cells.
Cancer Research 39, 1051-1055 (1979)

31.
K.W. van de Poll, J.M. Van Aken and R. Van Wijk
Induction of tyrosine aminotransferase by dibutyryl cyclic AMP in synchronized hepatoma cells.
Cell Biology International Reports 3, 247-255 (1979)

32.
R. Van Wijk and K.W. van de Poll
Variability of generation times in a hepatoma cell pedigree.
Cell and Tissue Kinetics 12, 659-663 (1979)

33.
R. Van Wijk, K.W. van de Poll and G. Zoutewelle
Regulation of initiation of DNA synthesis in relation to mitosis in cultured Hepatoma cells.
Cell Biology International Reports 3, 447-452 (1979)

34.
R. Van Wijk, G. Zoutewelle, N. Defer, L. Tichonicky and J. Kruh
Vatiations in some molecular events during the early phases of the Reuber H35 hepatoma cell cycle. Part 1. Glucocorticoid induction of tyrosine transaminase.
Biochimie 61, 711-717 (1979)

35.
N. Defer. L.Tichonicky, J. Kruh, G. Zoutewelle and R. Van Wijk
Variations in some molecular events during the early phases of the Reuber H35 cell cycle Part 2. Chromatin protein phosphorylation and protein kinases.
Biochimie 61, 855-859 (1979)

36.
A. van Meeteren, J. Van Rijn, W.A.M. Linnemans and R. Van Wijk
Effects of hyperthermia on ultrastructure, protein synthesis and survival of Reuber H35 hepatoma cells in culture.
Cells and Tissue Kinetics 13, 217 (1980)

37.
J. Van Rijn, A. van Meeteren and R. Van Wijk
Effect of dibutyryl cyclic AMP on the radiation response of tumor cells.
Cell and Tissue Kinetics 13, 218 (1980)

38.
R. Van Wijk, K.W. van de Poll and R. Roosendaal
Regulation of the rat hepatoma cell cycle.
Cell and Tissue Kinetics 13, 218 (1980)

39.
D.H.J. Schamhart, W.A.M. Linnemans and R. Van Wijk
Effect of hyperthermia on the nucleus of cultured hepatoma cells.
Archives Internationales de Physiologie et de Biochimie 88, B 204 (1980)

40.
H. Volman and R. Van Wijk
Protein content of mitochondria from cultured hepatoma cell lines and from isolated rat liver cells.
Archives Internationales de Physiologie et de Biochimie 88, B 214 (1980)

41. G.T. Snoek and R. Van Wijk
A posttranscriptional site of cAMP action is localised on the level of initiation of protein synthesis.
European Journal of Cell Biology 22, 143 (1980)

42.
R. Van Wijk, A. van Meeteren and B.F. Deys
The effects of X-irradiation on the intermitosis time and the occurence of cell death in mouse osteosarcoma cells.
Radiation and Environmental Biophysics 17, 365 (1980)

43.
R. Van Wijk and H.A.P.M. Louwers
The influence of a single administration of carcinogens on ornithine decarboxylase activity in primary cultered rat hepatocytes.
In Vitro 16, 206 (1980)

44.
G.T. Snoek, H.O. Voorma and R. Van Wijk
A Posttranscriptional site of induction of tyrosine aminotransferase by dexamethasone in Reuber H35 hepatoma cells.
FEBS Letters 125, 266-270 (1981)

45.
A. van Meeteren, G. Zoutewelle and R. Van Wijk
Differential commitment of DNA synthesis and mitosis in Reuber H35 rat hepatoma cells.
Cell Biology International Reports 5, 467 (1981)

46.
R. van Haarlem, R, Van Wijk and A.H.M. Fikkert
Analysis of the variability in cleavage times and demonstration of a mitotic gradient during the cleavage stages of Nothobranchius guentheri.
Cell and Tissue Kinetics 14, 285-300 (1981)

47.
G.T. Snoek, H.O. Voorma and R. Van Wijk
Further evidence for translational regulation of tyrosine aminotransferase synthesis by Dibutyryl cyclic AMP in Reuber H35 hepatoma cells.
Biochimica Biophysica Acta 655, 107-112 (1981)

48.
G.T. Snoek, K.W. van de Poll, H.O. Voorma and R. Van Wijk
Studies on the posttranscriptional site of cAMP action in the regulation of the synthesis of tyrosine aminotransferase.
European Journal of Biochemistry 114, 27-31 (1981)

49.
R. Van Wijk, H.A.P.M. Louwers and A. Bisschop
The induction of ornithine decarboxylase and DNA synthesis in rat hepatocytes after a single administration of diethylnitrosamine.
Carcinogenesis 2, 27-31 (1981)

50.
R. Van Wijk, L. Tichonicky and J. Kruh
Effect of sodium butyrate on the hepatoma cell cycle: Possible use for cell synchronization.
In Vitro 17, 859-862 (1981)

51.
A. Bisschop, L.A.A. van Rooyen, H.J.G.H. Derks and R. Van Wijk
Induction of rat hepatic ornithine decarboxylase by the tumor promoters 12-0-tetradecanoylphorbol-13-acetate and phenobarbital in vivo; effect of retinyl acetate.
Carcinogenesis 2, 1283-1287 (1981)

52.
A. van Meeteren, C. Loesberg, J. Van Rijn and R. Van Wijk
Cyclic AMP and the proliferation of Reuber H35 cells in vitro.
Advances in Cyclic Nucleotide Research 14, 680 (1981)

53.
G.T. Snoek and R. Van Wijk
Cyclic AMP induction of tyrosine aminotransferase synthesis is not dependent on the presence of untranslatable messenger RNA.
Advances in Cyclic Nucleotide Research 14, 681 (1981)

54
D.H.J. Schamhart, J. Van Rijn, H.S. van Walraven, F.A.C. Wiegant, and R. Van Wijk
Development of thermotolerance in cultured Reuber H35 hepatoma cells.
Strahlentherapie 157, 622 (1981)

55.
R. Van Wijk,D.H.J. Schamhart, W.A.M. Linnemans, L. Tichonicky and J. Kruh
Effect of hyperthermia on nuclear morphology and phosphorylation of nonhiston chromosomal proteins in cultured hepatoma cells.
National Cancer Institute Monograph 61, 49-51 (1982)

56.
Z. Streumer-Svobodova, F.A.C. Wiegant, A.A.M.S. van Dongen and R. Van Wijk
Variations in some molecular events during the early phases of the Reuber H35 hepatoma cell cycle. Part 3. Role of protein synthesis in the initiation of DNA synthesis and the mechanism of stimulation of protein synthesis by serum.
Biochimie 64, 411-418 (1982)

57.
C. Loesberg, J.C. van Miltenburg and R. Van Wijk
Heat production of Reuber H35 rat hepatoma cells under normo- and hyperthermia conditions.
Journal of Thermal Biology 7, 87-90 (1982)

58
C.Loesberg, J.C. van Miltenburg and R. Van Wijk
Heat production of mammalian cells at different cell cycle phases.
Journal of Thermal Biology 7, 209-213 (1982)

59.
G.T. Snoek, H.O. Voorma and R. Van Wijk
Positive and negative cAMP-mediated control of tyrosine aminotransferase synthesis in Reuber H35 hepatoma cells.
European Journal of Biochemistry 123, 217-222 (1982)

60.
A. van Meeteren, C. Loesberg, J. Van Rijn and R. Van Wijk
The effects of cyclic 3',5' ademosine monophosphate in the proliferation of Reuber H35 rat hepatoma cells in vitro.
In Vitro 18, 819-899 (1982)

61.
R. van Haarlem, J.G.B. Konings and R. Van Wijk
Analysis of the relationship between the variation in intercleavage times and cell diversification during the cleavage stages of the teleost fish Nothobrachius guentheri.
Cell and Tissue Kinetics 16, 167-176 (1983)

62.
R. van Haarlem, R. Van Wijk and J.G.B. Konings
Analysis of the variability and of the lengthening of intercleavage times during the cleavage stages of Nothobrachius guentheri.
Cell Tissue Kinetics 16, 177-187 (1983)

63.
C. Janssen-Dommerholt, R. Van Wijk and W.L.M. Geilenkirchen
Restriction of developmental potential and trochoblast ciliation in Patella embryos.
Journal of Embryology and experimental Morphology 74, 69-77 (1983)

64.
J. Van Rijn, J. van den Berg, A. van Meeteren and R. Van Wijk
Effects of exogenous cyclic AMP on growth characteristics and radiation response of Reuber H35 hepatoma cells.
Radiation Research 95, 262-272 (1983)

65.
R. Van Wijk
Regulation of DNA synthesis in cultured rat hepatoma cells.
International Review of Cytology 85, 63-107 (1983)

66.
R. Van Wijk, C. Loesberg and G.T. Snoek
Variations in some molecular events during the early phases of the Reuber H35 hepatoma cell cycle. Part 4. Regulation induction of tyrosine aminotransferase.
Biochimie 65, 643-652 (1983)

67.
A. van Meeteren, R. Van Wijk, J. Stap and B.F. Deijs
Analysis of X-ray inducted cell cycle pertubations in mouse osteosarcoma cells : a two signal cell cycle model.
Cell and Tissue Kinetics 17, 105-116 (1984)

68.
D.H.J. Schamhart, H.S. van Walraven, F.A.C. Wiegant, W.A.M. Linnemans, J. Van Rijn, J. van den Berg and R. Van Wijk
Thermotolerance in cultured hepatoma cells : cell viability, cell morphology, protein synthesis and heat shock proteins.
Radiation Research 98, 82-95 (1984)

69.
R. Van Wijk, J. Souren, D.H.J. Schamhart and J.C. van Miltenburg
Comparative studies of the heat production of different rat hepatoma cells in culture.
Cancer Research 44, 671-673 (1984)

70.
J. Van Rijn, J. van den Berg, D.H.J. Schamhart and R. Van Wijk
Effect of thermotolerance on thermal radiosensitization in hepatoma cells.
Radiation Research 97, 318-328 (1984)

71.
J. Boonstra, D.H.J. Schamhart, S.W. de Laat and R. Van Wijk
Analysis of K+ and Na+ transport and intracellular contents during and after heat shock and their role in protein synthesis in rat hepatoma cells.
Cancer Research 44, 955-960 (1984)

72.
A. Bisschop, O. Bakker, J.H.N. Meerman, R. Van Wijk, C.A. van der Heijden and J.E.C. Stavenuiter
Induction of ornithine decarboxylase and augmentation of tyrosine aminotransferase activity by N-hydroxy-2-acetyl-aminofluorene and 2-acetylaminofluorene in rat liver. Influence of sex, retinylacetate, indomethacin and pentachlorophenol.
Cancer Investigations 2, 267-277 (1984)

73.
J. Van Rijn, J. van den Berg, D.H.J. Schamhart and R. Van Wijk
Morphological response and survival of hepatoma cells during fractionated hyperthermia: effect of glycerol.
Radiation Research 98, 471-478 (1984)

74.
R. Van Wijk, A.M. Otto and L. Jimenez de Asua
Effect of serum and growth factors on heat sensitivity in Swiss mouse 3T3 cells.
Journal of Cellular Physiology 119, 155-162 (1984)

75.
L.A.A. van Rooijen, H.J.G.M. Derks, R. Van Wijk and A. Bisschop.
Relation between induction of rat hepatic ornithine decarboxylase activity by tumor promoters 12-0-tetra decanoylphorbol-13-acetate and phenobarbital and levels of the polyamines putrescine, spermidine and spermine, in vivo: differential effects of retinylacetate.
Carcinogenesis 5, 225-229 (1984)

76.
R. Van Wijk, A.M. Otto and L.Jimenez de Asua
Hyperthermia can enhance the initiation of DNA synthesis stimulated by growth factors in Swiss mouse 3T3 cells.
Experimental Cell Research 153, 522-527 (1984)

77.
D.H.J. Schamhart, W. Berendsen, J. Van Rijn and R. Van Wijk
Comparative studies of heat sensitivity of several rat hepatoma cell lines and hepatocytes in primair culture.
Cancer Research 44, 4507-4516 (1984)

78.
G.van Dongen, L. van de Zande, D.Schamhart and R. Van Wijk
Comparative studies on the heat-induced thermotolerance of protein synthesis and cell division in synchronized mouse neuroblastoma cells.
International Journal of Radiation Biology 46, 759-769 (1984)

79.
R. Van Wijk and W.L.M. Geilenkirchen
70K dalton protein synthesis and heat sensitivity of chromatin structure: dependence on cell cycle.
In: Growth, Cancer and the Cell Cycle. Ed. P.Skehan and S.J. Friedman. The Humana Press Inc., Clifton (1984) pp. 135-142.

80.
R. Van Wijk and W.L.M. Geilenkirchen
Cell cycle dependent heat sensitivity of chromatin structure and its relation to 70K dalton synthesis.
Cell and Tissue Kinetics (1984)

81.
R. Van Wijk
Growth factors and heat sensitivity - Heat shock and growth factor sensitivity.
Biology of the Cell 50, 5a (1984)

82.
J. Boonstra, F. Sybesma and R. Van Wijk
Regulation of DNA- and protein synthesis by K+ and Na+ after hyperthermia in hepatoma cell lines HTC and Reuber H35.
In: Hyperthermic Oncology 1984. Ed. J.Overgaard. Taylor & Francis, London and Philadelphia (1984) pp.7-10

83.
G. van Dongen, G. Zoutewelle and R. Van Wijk
Thermosensitization of neuroblastoma cells.
In: Hyperthermic Oncology 1984. Ed. J.Overgaard. Taylor & Francis, London and Philadelphia. (1984) pp. 11-14.

84.
R. Van Wijk
Hyperthermia can enhance proliferation of Swiss mouse 3T3 cells.
In: Hyperthermic Oncology 1984. Ed. J.Overgaard. Taylor & Francis, London and Philadelphia (1984) pp.15-18

85.
W. Linnemans, R. Van Wijk and W. Geilenkirchen
Nuclear morphology, chromatin structure and cell cycle dependent hyperthermic alterations.
In: Hyperthermic Oncology 1984. Ed. J.Overgaard. Taylor & Francis, London and Philadelphia (1984) pp.69-72

86.
D. Schamhart, J. Van Rijn and R. Van Wijk
Degree of differentiation and heat sensitivity of cultured hepatoma cells.
In: Hyperthermic Oncology 1984. Ed.J.Overgaard. Taylor & Francis, London and Philadelphia (1984) pp.103-106

87.
J. Van Rijn, J. van den Berg and R. Van Wijk
Modification of thermal radiosensitization in hypothermic cells.
In: Hyperthermic Oncology 1984. Ed. J.Overgaard. Taylor & Francis, London and Philadelphia (1984) pp.289-292

88.
F. Sybesma and R. Van Wijk
Hyperthermie als kankertherapie
Vakblad voor Biologen 64, 482-483 (1984)

89.
D.H.J. Schamhart, J. Boonstra, M. van Graft, J. Van Rijn and R. Van Wijk
The occurrence of thermotolerance in non-proliferating rat hepatocytes in primary culture.
International Journal of Radiation Biology 47, 213-218 (1985)

90.
A. Bisschop, P.M.J. Vankan, B. Uyterwaal and R. Van Wijk
Effect of 1.8-dihydroxy-9-anthrone (anthralin) on rat hepatic ornithine decarboxylase activity in vivo.
Cancer Letters 23, 151-157 (1984)

91.
J. Boonstra, F. Sybesma and R. Van Wijk
Effect of external K+ on protein and DNA synthesis during and after heat shock in rat hepatoma cells.
International Journal of Hyperthermia 3, 255-263 (1985)

92.
J. Van Rijn, J. van den Berg, J.B.A. Kipp, D.H.J. Schamhart and R. Van Wijk
Effect of hypothermia on cell kinetics and response to hyperthermia and X-rays.
Radiation Research 101, 292-305 (1985)

93.
R. Van Wijk, A.M. Otto and L. Jimenez de Asua
Increase of epidermal growth factor-stimulated cell-cycle progression and induction of thermotolerance by heat shock: temperature and time relationship.
International Journal of Hyperthermia 1, 147-156 (1985)

94.
L.A.A. van Rooyen, H.J.G.M. Derks, R. Van Wijk and A. Bisschop
Stimulation by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine of rat hepatic polyamine biosynthesis in vivo.
International Journal of Biochemistry 17, 839-842 (1985)

95.
C. Loesberg, R. Van Wijk, J. Zandbergen, W.G. van Aken, J.A. van Mourik and Ph.G. de Groot
Cell cycle dependent inhibition of human vascular smooth muscle cell proliferation by prostaglandin E1.
Experimental Cell Research 160, 117-125 (1985)

96.
G. van Dongen, G. Zoutewelle, J. Van Rijn and R. Van Wijk
Cell killing and sensitization to heat shock by hypothermic incubation of asynchronous and synchronized mouse neuroblastoma cells.
Cancer Research 45, 4132-4137 (1985)

97.
D.H.J. Schamhart, J. van Aken, J. Van Rijn and R. Van Wijk
Thermosensitization of hepatoma cells induced by sub- and supranormal temperatures.
Strahlentherapie 161, 549 (1985)

98.
G. van Dongen and R. Van Wijk
Effect of serum on the heat response of synchronized mouse neuroblastoma cells: protection of cell division and survival.
Strahlentherapie 161, 553 (1985)

98A
P.M.P. van Bergen en Henegouwen, W.J.R.M. Jordi, G. van Dongen, F.C.S. Ramaekers, H. Amesz and W.A.M. Linnemans
Studies on a possible relationship between alterations in the cytoskeleton and induction of heat shock protein synthesis in mammalian cells.
International Journal of Hyperthermia 1, 69 – 83 (1985)

99.
R. Van Wijk, A.A.M.S. van Dongen, L. Tichonicky and J. Kruh
Cell cycle dependent thermosensitivity of non histone chromosomal protein (NHCP) phosphorylation.
European Journal of Cell Biology 38, 28 (1985)

100.
R.Van Wijk and E.K. Boon-Niermeijer
Two types of thermotolerance induced in mouse 3T3 cells and 3-day old larvae of Lymnaea.
In: Thermoregulation and Adaption. Biona Reports 4. Eds. H. Laudien. Gustav Fisher Verlag, Stuttgart, New York (1986) pp. 85-92.

101.
G. van Dongen and R. Van Wijk
Effect of serum on heat response of synchronized mouse neuroblastoma cells: Protection of cell cycle progression, protein synthesis and survival.
International Journal of Radiation Biology 50, 77-91 (1986)

102.
G. van Dongen, W.L.M. Geilenkirchen, J. Van Rijn and R. Van Wijk
Increase of thermoresistance after growth stimulation of resting Reuber H35 hepatoma cells. Alteration of nuclear characteristics, non-histone chromosomal protein phosphorylation and basal heat shock protein synthesis.
Experimental Cell Research 166, 427-435 (1986).

103.
L. van de Zande, R. Kunnen, B. Uyterwaal, R. Van Wijk and A. Bisschop
Effect on hepatic ornithine decarboxylase of some food additives and synthetic elastomers.
Food Additives and Contaminants 3, 57-63 (1986).

104.
D.H.J. Schamhart and R. Van Wijk
Photon emission and the degree of differentiation.
In: Photon Emission from Biological Systems. Eds. B. Jezowska-Trebiatowska, J. Slawinski and B. Kochel World Scientific Publ. Co. Singapore, London. (1987) pp.137-152.

105.
P.M.P. van Bergen en Henegouwen, G. Berbers, W.A.M. Linnemans and R. Van Wijk
Subcellular localization of the 84000 dalton heat-shock protein in mouse neuroblastoma cells: evidence for a cytoplasmic and nuclear location.
European Journal of Cell Biology 43, 469-476 (1987).

105A.
P.M.P. van Bergen en Henegouwen and W.A.M. Linnemans
Heat shock gene expression and cytoskeletal alterations in mouse neuroblastoma cells.
Experimental Cell Research 171, 367-375 (1987)

105B.
F.A.C. Wiegant, P.M.P. van Bergen en Henegouwen, G. van Dongen and W.A.M. Linnemans
Stress-induced thermotolerance of the cytoskeleton of mouse neuroblastoma N2A cells and rat Reuber H35 hepatoma cells.
Cancer Research 47, 1674-1680 (1987)

106.
E.K. Boon-Niermeijer, J.E.M. Souren and R. Van Wijk
Thermotolerance induced by 2,4-dinitrophenol.
International Journal of Hyperthermia 3, 133-141 (1987).

107.
E.K. Boon-Niermeijer, J.E.M. Souren, A.M. de Waal and R. Van Wijk
Thermotolerance induced by heat and ethanol
International Journal of Hyperthermia 4, 211-217 (1988).

107A.
E.K. Boon-Niermeijer
Heat shock effects in snail development.
In: Results and Problems in Cell Differentiation. Vol. 17: Heat Shock and Development. Eds. Hightower and Nover. Springer Verlag. Berlin, Heidelberg. (1991) pp. 7-28.

108.
G. van Dongen and R. Van Wijk
Evidence for a role of heat-shock proteins in proliferation after heat treatment of synchronized mouse neuroblasoma cells.
Radiation Research 113, 252-262 (1988).

109.
R. Van Wijk and D.H.J. Schamhart
Regulatory aspects of low intensity photon emission.
Experientia 44, 586-593 (1988)

110.
E.K. Boon-Niermeijer, A.M. de Waal, J.E.M. Souren and R. Van Wijk
Heat-inducted changes in thermosensitivity and gene expression during development.
Development Growth & Differentiation 30, 705-715 (1988)

111.
G.A.M. Berbers, R. Kunnen, P.M.P. van Bergen en Henegouwen and R. Van Wijk
Localization and quantitation of hsp84 in mammalian cells.
Experimental Cell Research 177, 257-271 (1988)

112.
J. Van Rijn, J. van den Berg, D.H.J. Schamhart, H.G. Keizer, H. Joenje and R. Van Wijk
Characterization of variant cell lines growing continuously at temperatures up to 41.5 C.
In: Hyperthermic Oncology 1988. Eds. T. Sugahara and M. Saito. Taylor and Francis, London (1989) pp. 80-81.

113.
R. Van Wijk and J. Van Rijn
Metabolic status and heat sensitivity.
In: Hyperthermic Oncology 1988. Eds. T. Sugahara and M. Saito. Taylor and Francis, London (1989) pp. 107-110.

114.
R. Van Wijk and M. Tuijl
Growth factors and growth state as modifier of cellular heat sensitivity: c-Fos and HSP84 m-RNA expression.
In: Hyperthermic Oncology 1988. Eds. T. Sugahara and M. Saito. Taylor and Francis, London (1989) pp.176-177

 
115.
J.E.M. Souren, M. Ponec and R. Van Wijk
Contraction of collagen by human fibroblasts and keratinocytes.
In Vitro Cellular & Developmental Biology 25, 1039-1045 (1989).

116.
R. Van Wijk, J.Souren and G. Zoutewelle
Immune-modulation by the extracellular matrix: the effect of Echinacea extract.
In: Matrixforschung in der Praeventivmedizin. Ed. H. Heine. Gustac Fischer Verlag, Stuttgart-New York (1989), pp 41-49.

117.
R. Van Wijk and F.A.C. Wiegant
Homeopathic remedies and pressure-induced changes in the galvanic resistance of the skin.
Van Wijk and Wiegant Publ., Utrecht. (1989).

118.
G. Zoutewelle & R. Van Wijk
Effects of Echinacea purpurea extract on fibroblast populated collagen lattice contraction
Phytotherapy Research 4 , 77-81 (1990).

119.
R. Van Wijk, H. van Aken & D.H.J. Schamhart
Delayed luminescence of rat hepatoma cells
In: Biological Luminescence. Eds. B. Jezowska-Trebiatowska, B. Kochel, J. Slawinsky, W. Strek. World Scientific Publ. Co., Singapore-London (1990) pp.460-469.

120.
R. Van Wijk, F.A.C. Wiegant and J.E.M. Souren
Electrodermaal en matrix onderzoek.
Foundation Alfred Vogel-prijs Publ., Elburg (1990).

121.
M.J.M. Tuijl, P.M.P. van Bergen en Henegouwen, R. Van Wijk & A.J. Verkleij
The isolated neonatal rat-cardiomyocyte used in an in vitro model for 'ischemia'. II. Induction of the 68 kDa heat shock protein.
Biochimica Biophysica Acta 1091, 278-284 (1991).

122.
R. Van Wijk and H. van Aken
Light-induced photon emission by rat hepatocytes and hepatoma cells.
Cell Biophysics 18, 15-29 (1991)

123.
M.J.M. Tuijl, J.A. den Boon, W.M.J. van Grunsven and R. Van Wijk
Responsiveness of the increase in c-fosmRNA levels depends on the induces and the cell's past.
Journal of Cellular Physiology 149, 44-49 (1991).

124.
P.C. Endler, W. Pongratz, R. Van Wijk, G. Kastberger and M. Haidvogl
Effects of highly diluted succussed thyroxine on metamorphosis of highland frogs.
Berlin Journal of Research in Homeopathy 1, 151-160 (1991).

125.
J. Van Rijn, J. van den Berg, H. van Aken and R. Van Wijk
Induction of thermotolerance and heat shock protein synthesis during nutritional deprivation.
International Journal of Hyperthermia 8, 377-394 (1992).

126.
R. Van Wijk and H. van Aken
Spontaneous and light-induced photon emission by rat hepatocytes and hepatoma cells.
In: Recent Advances in Biophoton Research and Application. Eds. F.A.Popp, K.H.Li, Q.Gu. World Scientific Publ Co, Singapore-London (1992) pp.207-230.

127.
R. van Wijk, J. Souren and H. Ovelgonne
The extracellular matrix, fibroblast activity and effect of Echinacea purpurea.
In: Normal Matrix and Pathological Conditions. Eds. H.Heine and P. Anastasiadis. G.Fisher Verlag, Stuttgart (1992) pp. 77-93.

128.
J.E.M. Souren, C. Schneidenberg, A.J. Verkleij and R. Van Wijk
Factors controlling the rhythmic contraction of collagen gels by neonatal heart cells.
In Vitro Cellular Developmental Biology 28, 199-204 (1992).

129.
R.Van Wijk
Photon emission, stress and disease. Introduction to multi-author review.
Experientia 48, 1029-1030 (1992).

130.
R.Van Wijk and J.H. van Aken
Photon emission in tumor biology.
Experientia 48, 1092-1102 (1992).

131.
D.H.J. Schamhart, G. Zoutewelle, H. van Aken and R. Van Wijk
Effects on the expression of heat shock proteins by step-down heating and hypothermia in rat hepatoma cells with a different degree of heat sensitivity.
International Journal of Hyperthermia 8, 701-716 (1992)

132.
J.H.Ovelgonne, A.W.J.M. Bol, W.C.J. Hop and R. Van Wijk
Mechanical agitation of very dilute antiserum against IgE has no effect on basophil staining properties.
Experientia 48, 504-508 (1992).

133.
R. Van Wijk
Homeopathic medicines in closed phials tested by changes in the conductivity of the skin: a critical evaluation. Blind testing and partial elucidation of the mechanism.
VSM Geneesmiddelen Publ., Alkmaar (1992).

134.
R. Van Wijk, H. van Aken and D.H.J. Schamhart
Temperature-dependency of the expression of heat-shock proteins in rat hepatoma cells with a different degree of heat sensitivity
International Journal of Hyperthermia 9, 137-150 (1993).

135.
M.J.M. Tuijl, S. Cluistra, C.M.M. van der Kruijssen and R. Van Wijk
Heat-induced unresponsiveness of heat shock gene expression is regulated at the transcriptional level.
International Journal of Hyperthermia 9, 125-136 (1993)

136.
J.E.M. Souren and R.Van Wijk
Fibroblastic cell cycling in collagen gels.
Cell Proliferation 26, 13-23 (1993).

137.
R. Van Wijk, M. Welters, J.E.M. Souren H.Ovelgonne and F.A.C. Wiegant
Serum-stimulated cell cycle progression and stress protein synthesis in C3H10T1/2 fibroblasts treated with sodium arsenite.
Journal of Cellular Physiology 155, 265-272 (1993)

138.
R. Van Wijk, H. van Aken, W. Mei and F. A. Popp
Light-induced photon emission by mammalian cells.
Journal of Photochemistry and Photobiology, B: Biology. 18, 75-79 (1993).

139.
F. A.C. Wiegant, J.E.M. Souren, H. Van Rijn and R. Van Wijk
Arsenite-induced sensitization and self-tolerance of Reuber H35 hepatoma cells.
Cell Biology and Toxicology. 9, 49-59 (1993).

140.
S. van Delft, P. Coffer, W. Kruijer and R. Van Wijk.
c-Fos induction by stress can be mediated by the SRE.
Biochemical Biophysical Research Communications 197, 542-548 (1993).

141.
H. Ooms, A.W.J.M. Bol, J.H. van Meer and R. Van Wijk.
Hormesis, een knelpunt in dosis-effectrelaties.
Pharmaceutisch Weekblad 128, 1118-1122 (1993).

142.
R. van Wijk and W.A.M. Linnemans
The basic regulatory system.
In: Biologische Information und Regulation. Ed. G.J. Lamoen. Haug Verlag, Heidelberg. (1993) pp. 36-62.

143.
R. Van Wijk, J.H. Ovelgonne, E. De Koning, K. Jaarsveld, J. Van Rijn and F.A.C.Wiegant.
Mild step-down heating causes increased levels of HSP68 and of HSP84mRNA and enhances thermotolerance.
International Journal of Hyperthermia 10, 115-125 (1994).

144.
R. Van Wijk, H. Ooms, F.A.C. Wiegant, J.E.M. Souren, J.H. Ovelgonne, J.M. van Aken and A.W.J.M. Bol.
A molecular basis for understanding the benefits from subharmful doses of toxicants.
Environmental Management and Health 5, 13-25 (1994).

144A.
R. Van Wijk, H. Ooms, F.A.C. Wiegant, J.E.M. Souren, J.H. Ovelgonne, J.M. van Aken and A.W.J.M. Bol.
A molecular basis for understanding the benefits from subharmful doses of toxicants.
.International Journal of Integrated Medicine 15, 4-13 (1997).

145.
F.A.C.Wiegant, J.E.M. Souren, J. Van Rijn and R. Van Wijk.
Stressor-specific induction of heat shock proteins in rat hepatoma cells.
Toxicology 94, 143-159 (1994)

146.
J. Van Rijn, J. van den Berg, F.A.C. Wiegant and R. Van Wijk.
Time-temperature relationship for step-down heling in normal and thermotolerant cells.
International Journal of Hyperthermia 10, 643-652 (1994)

147.
J.E.M. Souren, R.C. Peters and R. Van Wijk.
Collagen gels populated with rat neonatal heart cells can be used for optical recording of rhythmic contractions which also show ECG-like potentials.
Experientia 50, 712-716 (1994).

148.
R. Van Wijk, F.A.C. Wiegant, F.A. Popp and G.E.M.G. Storms
Biophoton emission from blood serum of diabetic patients.
Progress in Biomedical Optics 2328, 212- 223 (1994)

149.
P.C. Endler, W. Pongratz, R. Van Wijk, F.A.C. Wiegant, K. Watl, M. Gehrer and H. Hilgers
A zoological example on ultra high dilution research. Energetic coupling between the dilution and the organism.
In: Ultra High Dilutions. Physiology and Physics. Eds. P.C. Endler and J. Schulte. Kluwer Academic Publ. Dordrecht (1994) pp. 39-68.

150.
R. Van Wijk and F.A.C. Wiegant
Physiological effects of homeopathic medicines in closed phials. A critical evaluation.
In: Ultra High Dilutions. Physiology and Physics. Eds. P.C. Endler and J. Schulte. Kluwer Academic Publ. Dordrecht (1994) pp. 81-95.

151.
P.C. endler, W. Pongratz, R. Van Wijk, K. Waltl, H. Hilgers and R. Brandmaier
Transmission of hormone information by nonmolecular means.
FASEB Journal 8, A400 (1994).

152.
R. Van Wijk and F.A.C. Wiegant
Cultured mammalian cells in homeopathy research. The similia principle in self-recovery.
Van Wijk and Wiegant Publ., Utrecht (1994).

153.
J.E.M. Souren, M.C.C. van Schoot and R. Van Wijk.
HSP synthesis of neonatal rat heart myocytes is regulated by a collagen environment.
International Journal of Hyperthermia 11, 257-266 (1995)

154.
H. Ovelgonne and R. Van Wijk.
Modulation of HSP68 gene expression after heatshock in thermosensitized and thermotolerant cells is not solely regulated by binding of HSF to HSE.
International Journal of Hyperthermia 11, 719-732 (1995)

155.
J. Van Rijn, J. van den Berg, F.A.C. Wiegant and R. Van Wijk.
Sensitization to X-rays by sodium arsenite or heat in normal cells and in cells with an induced tolerance for heat and arsenite.
Radiation, Environment and Biophysics 34, 169-175 (1995)

156.
J. Van Rijn, J. van den Berg, J.E.M. Souren, R. Van Wijk and H. Joenje
Hepatoma cells adapted to proliferate under normally lethal hyperthermic stress conditions show rapid decay of thermoresistance and heat shock protein synthesis when returned to 37 C.
International Journal of Hyperthermia 11, 697- 708 (1995)

157.
J.H. Ovelgonne, F.A.C. Wiegant, J.E.M. Souren, J. Van Rijn and R. Van Wijk
Enhancement of the stress response by low concentrations of arsenite in arsenite-pretreated Reuber H35 hepatoma cells.
Toxicology and Applied Pharmacology 132, 146-155 (1995)

158.
J.H. Ovelgonne, J.E.M. Souren, F.A.C. Wiegant and R. Van Wijk
Relationship between cadmium induced expression of heat shock genes, inhibition of protein synthesis and cell death.
Toxicology 99, 19-30 (1995)

159.
R. Van Wijk and F.A.C. Wiegant
Stimulation of self-recovery by similia principle? Mode of testing in fundamental research.
British Homeopathic Journal 84, 131-139 (1995)

160.
R. Van Wijk, J.H. van Aken and J.E.M. Souren
Ultraweak delayed photon emission and light scattering of different mammalian cell types.
In: Biophotonics, Non equilibrium and Coherent Systems in Biology, Biophysics and Biotechnology. Ed. L. Beloussov, F.A. Popp. Bioinform Serv Co., Moscow, Russia. 1995. pp. 221-232.

161.
H. Ovelgönne, M. Bitorina and R. Van Wijk
Stressor-specific activation of heat shock genes in rat hepatoma cells.
Toxicology and Applied Pharmacology 135, 100-109 (1995)

162.
R. Van Wijk, J.M. van Aken, H.E. Laerdal and J.E.M. Souren
Relaxation dynamics of light-induced photon emission by mammalian cells and nuclei.
Progress in Biomedical Optics, 2627, 176-185 (1995)

163.
J.H. Ovelgönne, R. Van Wijk, A.J. Verkleij and J.A. Post
Cultured neonatal rat heart cells can be preconditioned by ischemia, but not by heat shock. The role of stress proteins.
Journal of Molecular and Cellular Cardiology 28, 1617-1629 (1996)

164.
R. Van Wijk and J.E.M. Souren
Relaxation dynamics of long-period photo-phosphorescence of mammalain cells.
In: Biological Effects of Light. Eds. M.F. Holick and E.G. Jung. Walter de Gruyter, Berlin, New York (1996) pp.145-147.

165
R. van Wijk, J.M. van Aken, H.E. Laerdal and J.E.M. Souren
Relaxation dynamics of light-induced photon emission by mammalian cells and nuclei.
In: Current Developments of Biophysics. Eds. C. Zhang, F.A. Popp and M. Bischof. Hangzhou University Press (1996) pp. .

166.
R. Van Wijk and F.A.C. Wiegant
Homoopathie in der aktuellen Forschung: Simile-Prinzip experimentell bestatigt?
Allgemeine Homoopathische Zeitung 241, 56-61 (1996)

167
F.A.C. Wiegant and R. Van Wijk
Self-recovery and the similia principle: an experimental model.
Complementary Therapics in Medicine 4, 90-97 (1996)

168
J.E.M. Souren, H. Van Aken and R. Van Wijk
Enhancement of superoxide production and protection against heat shock by HSP27 in fibroblasts.
Biochemical and Biophysical Research Communications 227, 816-821 (1996).

169.
F.A.C. Wiegant, N. Spieker, C.A. van der Mast and R. Van Wijk
Is heat shock protein re-induction during tolerance related to the stressor-specific induction of heat shock proteins?
Journal of Cellular Physiology, 169, 364-372 (1996).

170.
F.A.C. Wiegant, J. Van Rijn and R. Van Wijk
Enhancement of the stress response by minute amounts of cadmium in sensitized Reuber H35 hepatoma cells.
Toxicology, 116, 27-37 (1997).

171.
F.A.C. Wiegant, J.H. Ovelgönne, J.E.M. Souren and R. Van Wijk
Stimulation of self-recovery by low doses of arsenite in arsenite-intoxicated cells.
In: Signals and Images. Ed. M. Bastide; Kluwer Academic Publishers, Dordrecht (1997) pp 41-51.

172.
R. Van Wijk and F.A.C. Wiegant
Stimulation of cellular self-recovery by application of the similia-principle.
In: Signals and Images. Ed. M. Bastide; Kluwer Academic Publishers, Dordrecht (1997) pp 53-61.

173.
R. Van Wijk and F.A.C. Wiegant
The similia principle as a therapeutic strategy: a research program on stimulation of self-defense in disordered mammalian cells.
Alternative Therapies 3, 33-38 (1997).

174.
R. Van Wijk, H.M. Van Aken and J.E.M. Souren
An evaluation of delayed luminescence of mammalian cells.
Trends in Photochemistry and Photobiology 4, 87-97 (1997).

175.
J.E.M. Souren, C. Van der Mast and R. Van Wijk
NADPH-oxidase dependent superoxide production by myocyte-derived H9c2 cells. Influence of ischemia, heat shock, cycloheximide and cytochalasin D.
Journal of Molecular and Cellular Cardiology 29, 2803-2812 (1997).

176.
G.C. Scheper, J. Mulder, M. Kleijn, H.O. Voorma, A.A.M. Thomas and R. Van Wijk
Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells.
Journal of Biological Chemistry. 272, 26850-26856 (1997).

177.
R. Van Wijk and F.A.C. Wiegant
Stimulation of cellular defence of stressed liver cells by subharmful doses of toxicants. Part 1. The Homint program on the similia principle.
Homint R&D Newsletter 1997 (1) 3-11

177A.
R. Van Wijk and F.A.C. Wiegant
Stimulation der zellularen Abwehr gestresster Leberzellen durch subtoxische Dosen von Schadstoffen. Teil 1. Das Homint-Program zur Untersuchung des Similia-Prinzips.
Homint R&D Newsletter 1997 (1) 3-11

178.
R. Van Wijk and F.A.C. Wiegant
Stimulation of cellular defence of stressed liver cells by subharmful doses of toxicants. Part 2.
Homint R&D Newsletter 1997 (2) 3-12

178A
R. Van Wijk and F.A.C. Wiegant
Stimulation der zellularen Abwehr gestresster Leberzellen durch subtoxische Dosen von Schadstoffen. Teil 2.
Homint R&D Newsletter 1997 (2) 3-12

179.
R. Van Wijk and F.A.C. Wiegant
The similia principle in surviving stress; mammalian cells in homeopathy research.
Van Wijk and Wiegant Publ., Utrecht (1997).

180.
A. Peper, C.A. Grimbergen, J.A.E. Spaan, J.E.M. Souren and R. Van Wijk
A mathematical model of the hsp70 regulation in the cell.
International Journal of Hyperthermia. 14, 97-124 (1998).

181.
R. Van Wijk and F.A.C. Wiegant
Homeopathy and the mammalian cell: Programmed cell recovery and new therapeutic strategies.
In: Homeopathy, A critical appraisal. Ed. E. Ernst; Butterworth-Heinemann, Oxford (1998) pp 180-190.

182.
R. Van Wijk and F.A.C. Wiegant
Stimulation of self-recovery by the application of low doses . Studies with cells.
In: High Dilution Effect on Cells and Integrated Systems. Eds. C. Taddei-Ferretti and P.Marotta. World Scientific Publ.Co, Singapore (1998) pp.76-87.

183.
R. Van Wijk and F.A.C. Wiegant
Stimulation of self recovery by application of the Similia principle.
In: High Dilution Effect on Cells and Integrated Systems. Eds. C. Taddei-Ferretti and P.Marotta. World Scientific Publ.Co, Singapore (1998) pp.145-153.

184.
F.A.C. Wiegant and R. Van Wijk
The state of enhanced sensitivity as optimal condition to study low dose effects.
In: High Dilution Effect on Cells and Integrated Systems. Eds. C. Taddei-Ferretti and P.Marotta. World Scientific Publ.Co, Singapore (1998) pp. 159-163.

185.
R. Van Wijk
Pressure-induced electrical skin conductivity as a sensitive mean for the detective by human-human interaction of subtle bodily changes.
In: High Dilution Effect on Cells and Integrated Systems. Eds. C. Taddei-Ferretti and P.Marotta. World Scientific Publ.Co, Singapore (1998) pp 273-282.

186.
R. Van Wijk and F.A.C. Wiegant
Stimulation of cellular defence and recovery by subharmfuldoses of toxicants: The homologous component of the similian principle.
In: Fundamental Research in Ultra High Dilution and Homeopathy. Eds. J.Schulte and P.C.Endler. Kluwer Academic Publ., Dordrecht (1998) pp. 215-228 .

187.
G.C. Scheper, A.A.M. Thomas and R. Van Wijk
Inactivation of eukaryotic initiation factor 2B in vitro by heat shock.
Biochemical Journal 334, 463-467 (1998)

188.
J.E.M. Souren and R. Van Wijk
Luminometry in cellular stress research.
In: Biophotons. Ed. J.J. Chang, J. Fisch, F.A. Popp. Kluwer Academic Publ., Dordrecht (1998) pp. 65-78.

189
F.A.C. Wiegant, N. Spieker and R. Van Wijk
Stressor-specific enhancement of hsp-induction by low doses of stressors in conditions of self- and cross-sensitization.
Toxicology 127, 107-119 (1998)

190.
F.A.C.Wiegant, J.E.M.Souren and R.Van Wijk
Stimulation of survival capacity in heat treated cells by subsequent exposure to minute amounts of chemical stressors; role of similarity in stressor effect.
In: Metal Ions in Biology and Medicin, Vol.5
Eds: Ph.Collery, P.Bratter, V.Negretti de Bratter, L.Khassanora, J.C.Etienne
J.Libbey Eurotext, Paris(1998) pp146-150

191.
F.A.V. Wiegant, J.E.M. Souren and R. Van Wijk
Stimulation of survival capacity in heat shocked cells by subsequent exposure to minute amounts of chemical stressors; role of similarity in hsp-inducing effects.
Human and Experimental Toxicology 18, 460-470 (1999)

192.
J.E.M.Souren, F.A.C.Wiegant and R.Van Wijk
The role of hsp70 in protection and repass of luciferase activity in vivo; experimental data and mathematical modelling.
Cellular and Molecular Life Sciences 55, 799-811 (1999)

193.
J.E.M.Souren, F.A.C.Wiegant, P.Van Hof, and R.Van Wijk
The effect of temperature and protein synthesis on the renaturation of firefly luciferase in intact H9C2 cells.
Cellular and Molecular Life Sciences 55, 1473-1481 (1999)

194.
R. Van Wijk, A. Scordino, A. Triglia, F. Musumeci.
Simultaneous measurements of delayed luminescence and chloroplast organization in Acetabularia acetabulum.
J. Photochem. Photobiol. 49, 142-149 (1999)

195.
R.Van Wijk
Homeopathy – The Similia Principle
In: KVC Jahrbuch 6, Eds: H.Albrecht, M.Fruehwald.
KVC Verlag, Essen (1999) pp.207-214

196.
J.E.M. Souren, E. Boon-Niermeijer and R. Van Wijk.
Germination capacity of tomato seeds and ultraweak photon-induced delayed luminescence.
In: Biophotonics and Coherent Systems, Eds. L Belloussov, F.A. Popp, V.Voeikov, R.Van Wijk. Moscow University Press (2000) pp. 419-430.

197.
R. Van Wijk.
Tote Molekule und lebende Zelle.
In: Elemente des Lebens, Eds. H.P.Duerr, F.A.Popp and W.Schommers
SFG Fachverlag, Kusterdingen (2000) pp. 155-177.

198.
J. van Rijn, F.A.C. Wiegant, J. van den Berg and R. Van Wijk
Heat shock response by cells treated with azetidine-2-carboxylic acid.
Int. J. Hyperthermia 16, 305-318 (2000)

199.
R. Van Wijk.
Bio-photons and bio-communication
Journal of Scientific Exploration 15, 183-197 (2001)

200.
G.C. Scheper, R. Van Wijk and A.A.M. Thomas
Regulation of the activity of Eukaryotics Initiation Factors in Stressed Cells.
In: Progress in Molecular and Subcellular Biology, vol 27,
Ed. R.E.Rhoads, Springer Verlag, Berlin Heidelberg (2001) pp.39-56.

201.
F. Wiegant, C. W. Kramers and R. Van Wijk
The importance of patient selection.
In: Clinical Research Methodology for Complimentary Therapies, Eds. G.T. Lewith and D. Aldridge. Churchill Livingstone, London, (2002) pp. 155-170


4.2. Publications on Biophoton Research

D.H.J. Schamhart and R. Van Wijk
Photon emission and the degree of differentiation.
In: Photon Emission from Biological Systems. Eds. B. Jezowska-Trebiatowska, J. Slawinski and B. Kochel World Scientific Publ. Co. Singapore, London. (1987) pp.137-.

R. Van Wijk and D.H.J. Schamhart
Regulatory aspects of low intensity photon emission.
E xperientia 44, 586-593 (1988)

R. Van Wijk, H. van Aken & D.H.J. Schamhart
Delayed luminescence of rat hepatoma cells
In: Biological Luminescence. Eds. B. Jezowska-Trebiatowska, B. Kochel, J. Slawinsky, W. Strek. World Scientific Publ. Co., Singapore-London (1990) pp.460-469.

R. Van Wijk and H. van Aken
Light-induced photon emission by rat hepatocytes and hepatoma cells.
Cell Biophysics 18, 15-29 (1991)

R. Van Wijk and H. van Aken
Spontaneous and light-induced photon emission by rat hepatocytes and hepatoma cells.
In: Recent Advances in Biophoton Research and Application. Eds. F.A.Popp, K.H.Li, Q.Gu. World Scientific Publ Co, Singapore-London (1992) pp.207-230.

R.Van Wijk
Photon emission, stress and disease. Introduction to multi-author review.
Experientia 48, 1029-1030 (1992).

R.Van Wijk and J.H. van Aken
Photon emission in tumor biology.
Experientia 48, 1092-1102 (1992).

R. Van Wijk, H. van Aken, W. Mei and F. A. Popp
Light-induced photon emission by mammalian cells.
Journal of Photochemistry and Photobiology, B: Biology. 18, 75-79 (1993).

R. Van Wijk, F.A.C. Wiegant, F.A. Popp and G.E.M.G. Storms
Biophoton emission from blood serum of diabetic patients.
Progress in Biomedical Optics 2328, 212- 223 (1994)

R. Van Wijk, J.H. van Aken and J.E.M. Souren
Ultraweak delayed photon emission and light scattering of different mammalian cell types.
In: Biophotonics, Non equilibrium and Coherent Systems in Biology, Biophysics and Biotechnology. Ed. L. Beloussov, F.A. Popp. Bioinform Serv Co., Moscow, Russia. 1995. pp. 221-232.

R. Van Wijk, J.M. van Aken, H.E. Laerdal and J.E.M. Souren
Relaxation dynamics of light-induced photon emission by mammalian cells and nuclei.
Progress in Biomedical Optics, 2627, 176-185 (1995)

R. Van Wijk and J.E.M. Souren
Relaxation dynamics of long-period photo-phosphorescence of mammalain cells.
In: Biological Effects of Light. Eds. M.F. Holick and E.G. Jung. Walter de Gruyter, Berlin, New York (1996) pp.145-147.

R. van Wijk, J.M. van Aken, H.E. Laerdal and J.E.M. Souren
Relaxation dynamics of light-induced photon emission by mammalian cells and nuclei.
In: Current Developments of Biophysics. Eds. C. Zhang, F.A. Popp and M. Bischof. Hangzhou University Press (1996) pp. .

J.E.M. Souren, H. van Aken and R. Van Wijk
Enhancement of superoxide production and protection against heat shock by HSP27 in fibroblasts.
Biochemical and Biophysical Research communications 227, 816-821 (1996)

R. Van Wijk, H.M. Van Aken and J.E.M. Souren
An evaluation of delayed luminescence of mammalian cells.
Trends in Photochemistry and Photobiology 4, 87-97 (1997

J.E.M. Souren, C. Van der Mast and R. Van Wijk
NADPH-oxidase dependent superoxide production by myocyte-derived H9c2 cells. Influence of ischemia, heat shock, cycloheximide and cytochalasin D.
Journal of Molecular and Cellular Cardiology 29, 2803-2812 (1997)

J.E.M. Souren and R. Van Wijk
Luminometry in cellular stress research.
In: Biophotons. Ed. J.J. Chang, J. Fisch, F.A. Popp. Kluwer Academic Publ., Dordrecht (1998) pp. 65-78.

J.E.M.Souren, F.A.C.Wiegant and R.Van Wijk
The role of hsp70 in protection and repass of luciferase activity in vivo; experimental data and mathematical modelling.
Cellular and Molecular Life Sciences 55, 799-811 (1999)

J.E.M.Souren, F.A.C.Wiegant, P.Van Hof, and R.Van Wijk
The effect of temperature and protein synthesis on the renaturation of firefly luciferase in intact H9C2 cells.
Cellular and Molecular Life Sciences 55, 1473-1481 (1999)

R. Van Wijk, A. Scordino, A. Triglia, F. Musumeci.
Simultaneous measurements of delayed luminescence and chloroplast organization in Acetabularia acetabulum.
J. Photochem. Photobiol. 49, 142-149 (1999)

J.E.M. Souren, E. Boon-Niermeijer and R. Van Wijk.
Germination capacity of tomato seeds and ultraweak photon-induced delayed luminescence.
In: Biophotonics and Coherent Systems, Eds. L Belloussov, F.A. Popp, V.Voeikov, R.Van Wijk. Moscow University Press (2000) pp. 419-430.

R. Van Wijk.
Tote Molekule und lebende Zelle.
In: Elemente des Lebens, Eds. H.P.Duerr, F.A.Popp and W.Schommers
SFG Fachverlag, Kusterdingen (2000) pp. 155-177.

R. Van Wijk.
Bio-photons and bio-communication
Journal of Scientific Exploration 15, 183-197 (2001)

5. Internet Publications:

• Deleayed Luminescence of Acetabularia. New perspectives, Roeland Van Wijk, Rafael Gaya Moreno, IIB-conference 2000
• Photon emission and germination capacity of tomato seeds, J.E.M. Souren, E. K. Boon-Niermeijer, R. Van Wijk, IIB-conference 1999