Dr. Hugo Niggli

Professional Information

Dr. Hugo Niggli was born on the 19th of July 1955 in Aarau (Switzerland) and graduated end of the seventies in biochemistry at the Swiss Federal Institute of Technology. Ph.D studies under the supervision of Professor P. Cerutti, the winner ot the Steiner prize on cancer research 1986, at the Swiss Institute for Experimental Cancer Research (ISREC). Promotion on the 25th of May 1983 with the thesis entitled: Formation and excision of cycobutane-type pyrimidine dimers in human skin fibroblasts after irradiation with ultraviolet light. From 1984 -1993 he worked as head of the cell culture laboratory on dermatological research at Cosmital SA in Marly (Switzerland), a Research Compan WELLA AG (Darmstadt, Germany). In August 1988 he encountered Professor Fritz-Albert Popp, the German pioneer in biophotonic research and worked together with him on biophoton emission in mammalian cells. In the year 1993 he founded the Institute of Integrative Photobiology, BioFoton AG, in order to do basic biophotonic research and his application in food quality control.

E-Mail-Adress: biofoton@swissonline.ch
Web-Site: http://www.homepage.swissonline.ch/biofoton
Phone and Fax (Office): 0041-26-4131445

1. Niggli, H.J. (1986) A new sensitive assay for detecting thymine containing pyrimidine dimers using HPLC. In: Cosmetic Dermatology, Vol. I (Edited by P. Morganti, W. Montagna). International Ediemme, Rome, Italy, pp 335-342.
2. Niggli, H.J. (1989) Kinetics of excision repair in human skin. J.Invest. Dermatol. , 92, 304.
3. Niggli, H.J. (1990) Comparative studies on the correlation between pyrimidine dimer formation and tyrosinase activity in Cloudman S91 melanoma cells after ultraviolet-irradiation. Photochem. Photobiol. 52, 519-524.
4. Niggli, H. J. (1992a) Determination of cytosine-cytosine photodimers in the DNA of Cloudman S91 melanoma cells using high pressure liquid chromatography. Photochem. Photobiol. 55, 793-796.
5. Niggli, H.J. (1992b) Biophoton re-emission studies in carcinogenic mouse melanoma cells. In Recent advances in biophoton research and its application (F.A. Popp and K.H. Li, editors). World-Scientific, Singapore.
6. Niggli, H. J. (1992c) Ultraweak photons emitted by cells: biophotons. J. Photochem. Photobiol. B, Vol 14., p144-146.
7. Niggli, H.J. (1993a) Artificial sunlight irradiation induces ultraweak photon emission in human skin fibroblasts, J. Photochem. Photobiol. B: Biol. 18, 281-285.
8. Niggli, H.J. (1993b) Aphidicolin inhibits excision repair of UV-induced pyrimidine photodimers in low serum cultures of mitotic and mitomycin C-induced postmitotic human skin fibroblasts, Mut. Res. 295, 125-133.
9. Niggli, H.J. (1996) The cell-nucleus of cultured melanoma cells as a source of ultraweak photon emission, Naturwissenschaften 83, 41-44.
10. Niggli, H.J. (1998a) UV-induced DNA damage and repair: A powerful light trapping system in DNA in order to convert light energy into biochemical signals, In: Biophotons (J. J. Chang, J. Fisch and F.-A. Popp (eds.)), Kluwer Academic Publishers, Dordrecht, Netherlands.
11. Niggli, H.J. (1998b) Biophotons: our body produces light!, Network 68, 16-17.
12. Niggli, H.J. Zur Diskussion gestellt: Lichtemissionen von Lebensmitteln, Erfahrungsheilkunde 48, 762-764, 1999.
13. Niggli, H.J. and P.A. Cerutti (1982) Nucleosomal distribution of thymine photodimers following far- and near-ultraviolet irradiation. BBRC 105, 1215-1223.
14. Niggli, H.J. and P.A. Cerutti (1983a) Cyclobutane-type pyrimidine photodimer formation and excision in human skin fibroblasts after irradiation with 313-nm ultraviolet light. Biochemistry 22, 1390-1395.
15. Niggli, H.J. and P.A. Cerutti (1983b) Temperature dependence of induction of cyclobutane-type pyrimidine photodimers in human fibroblasts by 313 nm light. Photochem. Photobiol. 37, 467-469.
16. Niggli, H.J. and P.A. Cerutti (1984) Formation and removal of pyrimidine photodimers in human skin fibroblasts irradiated with near-ultraviolet light. In Proceedings of the 13th Hoechst Workshop Conference on "Biochemical Basis of Chemical Carcinogenesis" in Grainau, 1982, (Greim, H., Jung, R., Kramer, M. Marquardt, H. and F. Oesch, editors) Raven Press, New York, pp 257-264.
17. Niggli, H.J. and P.I. Francz (1992) May ultraviolet light-induced ornithine decarboxylase response in mitotic and postmitotic human skin fibroblasts serve as a marker of aging and differentiation?, Age 15, 55-60.
18. Niggli, H.J. and R. Röthlisberger (1986) Determination of lysosomal acid phosphatase in human skin as a marker of irritation following different surfactant treatments. J. Soc. cosmet. Chem 37, 387-393.
19. Niggli, H.J. and R. Röthlisberger (1988a) Sunlight-induced pyrimidine dimers in human skin fibroblasts in comparison with dimerization after artificial UV-irradiation. Photochem. Photobiol. 48, 353-356.
20. Niggli, H.J. and R. Röthlisberger (1988b) Cyclobutane-type pyrimidine photodimer formation and induction of ornithine decarboxylase in human skin fibroblasts after UV irradiation. J.Invest. Dermatol. 91, 579-584.
21. Niggli, H.J. and L.A. Applegate (1997) Glutathione response after UVA-irradiation in mitotic and postmitotic human skin fibroblats and keratinocytes, Photochem. Photobiol. 65, 680-684.
22. Niggli, H.J., K. Bayreuther, H.P. Rodemann, R. Röthlisberger and P.I. Francz (1989) Mitomycin C-induced postmitotic fibroblasts retain the capacity to repair pyrimidine photodimers formed after UV-irradiation. Mutation Res. 219, 231-240.
23. Niggli H.J, C. Scalet, F.A Popp, Y. Yu, and L.A. Applegate. Ultraweak photon emission in assessing growth factor efficiency using fibroblastitic differentiation. Journal of Photochemistry and Photobiology B: Biology 64 (2001) 62-68.
24. Niggli H.J., Scaletta, C., Y. Yu, F.A. Popp and L.A. Applegate. UV-induced DNA damage and ultraweak photon emission in human fibroblastic skin cells: parameters to trigger intra- and extra-cellular photobiostimulation. Trends in Photochemistry and Photobiology, Vol. 8 (2001), 55-65.
25. Applegate, L.A. , Scaletta, C. Panizzon, R., Niggli, H. and E. Frenk: In vivo induction of pyrimidine dimers in human skin by UVA radiation: Initiation of cell damage and/or intercellular communication. Intern. J. of Molecular Med. 3, 467-472, 1999.
26. Applegate L.A., C. Scaletta and H.J. Niggli. Ultraweak photon emission in human skin cells : Is UV-induced DNA damage involved in intra-and extra-cellular photobiostimulation? In: Biophotonics and Coherent Systems (L. Beloussov, F.A. Popp, V. Voeikov and R. van Wijk, eds). Proceedings of the 2nd Alexander Gurwitsch Conference, Moscow University Press, 2000, p 367-380.