Conference on Biophotons 1999 - MECHANOEMISSION OF BLOOD AND ONCOGENESIS

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Conference on Biophotons 1999
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MECHANOEMISSION OF BLOOD AND ONCOGENESIS

Valeri E. Orel and Natalia N. Dzyatkovskaya

Physico-Techical Laboratory, Ukrainian Research Institute of Oncology and Radiology 33/43 Lomonosov str 252022 Kyiv-22 Ukraine Fax (044) 2660198, E-mail: orel@ucr.kiev.ua

Introduction. Oncogenesis is accompanied by atypical changes of cell shapes and by increase of mechanical stresses exerted by the uncontrollable growing malignant cells. Whereas during normal ontogenesis the mechanochemical factors participate in shape-forming regulatory feedback in oncogenesis these very factors disorganize cell differentiation. On the other hand, the mechanochemical factors can initiate a wide range of mechanoemission (ME) phenomena including optical and radioemission of biological objects. The latter phenomena are based upon electrophysiological and free radical processes. Based upon Gurwitsch's theory of morphogenetic field and a concept of a molecular chaos in pathophysiology we consider the malignant tumor growth as a result of an impaired self-organization in biological systems.

Materials and methods. We have studied experimentally induced Lewis carcinoma and Ehrlich ascitic cancer (C57BL/6 mice), Guerin's carcinoma and sarcoma 45 (unstrained white rats). For clinical investigations the patients with aesophagus, cardia, rectum and stomach cancer have been used as well as the persons with inflammations of gastric mucosa and the virtually healthy individuals. Blood probes have been taken from mice after their decapitation, from the tail veins of mice and from a left hand finger from humans. Blood ME has been recorded with the use of a program-apparatus device TPA-3 (1).

Results and discussion. By employing the models of transplanted tumors of Guerin's carcinoma, sarcoma 45 and Ehrlich ascite cancer we could show a correlation between the kinetics of blood ME and the kinetics of neoplasia. Blood ME kinetics in mice with Lewis carcinoma correlated with the size of the primary tumor and the intensity of metastasis. A decrease in the primary tumor growth intensity and the inhibition in metastasizing have been correlated with a diminishing of a chaotic dynamics in blood ME. In cancer patients, blood ME showed a more pronounced fluctuating dynamics than in the healthy ones. On the other hand, a pronounced blood ME periodicity has been revealed in the patients with inflammatory diseases which may point to some kind of adaptive vascular-tissue response. Similarly to the data obtained on animals the cancer patients with intensive metastasizing exhibited an increasing aperiodicity of blood ME. In the normal subjects and inflammation patients the ME kinetics is of an intermediate nature. Our results permit to consider oncogenesis as an expression of impairments in the homeostatical molecular determined chaos.

Reference. Orel V.E. et al. (1994) Physical and engineering principles in the study of mechanically-induced emission of blood. Biomedical Engineering 28: 335-341 (in Russian).

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