INTERNATIONAL INSTITUTE OF BIOPHYSICS
Conference on Biophotons 1999
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ULTRAWEAK PHOTON EMISSION IN DIFFERENTIATED FIBROBLASTS

Hugo J. Niggli

BioFoton AG, Rte. d'Essert , CH-1733 Treyvaux (FR) Switzerland (P.O. Box 28, CH-1731 Ependes) Phone/Fax: 0041-264131445 E-mail: biofoton@mail.swissonline.ch

Photons participate in many atomic and molecular interactions and changes. Recent biophysical research has shown the existence of ultraweak photons in biological tissue. It is now established that plants, animal and human cells emit a very weak radiation which can be readily detected with an appropriate photomultiplier system. Although the emission is extremely low in mammalian cells, it can be efficiently induced by ultraviolet light. It was recently reported that UV-light elevates ultraweak photon emission at least by a factor of 2 in mitomycin C (MMC)-induced postmitotic Xeroderma pigmentosum (XP)-fibroblasts, the final stage of the fibroblast ageing system described by Bayreuther and co-workers, compared to mitotic XP-cells. All of these results confirm the highly interesting biophoton model published in 1983 by Nagl and Popp which suggests that there is a negative feedback loop in living cells which couples states of a coherent ultraweak photon field with the conformational state of cellular DNA. They postulate photon transfer from the cytoplasmic metabolism to the DNA which results in changes of DNA conformation via excimer formation. Since the conformation of the DNA molecule is believed to be of importance for the regulation of nuclear information transfer, such processes in turn influence the metabolic activity of the cell. Ultraweak photons are measured in the visible and the UV-range. Photons in the visible range are coupled with radical reactions induced by oxidant stress while photons in the UV are linked with the DNA as the source. Preliminary experiments following UV-light irradiation show significant ultraweak photon emission changes in distinct differentiation stages of the fibroblast system and therefore, the sources and the mechanisms of this very weak photon emission was investigated using the distinct differentiating stages of fibroblasts. It was found, that ultraweak photons serve as excellent tools in the fibroblast differentiation system to unravel further aging and cancer mechanisms of human skin.
 

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